Non-Stim Pre Exercise Now with Nitrosigine (2023 V3)

L-Citrulline – 6,000 mg

Citrulline is an amino acid that packs a robust punch in relation to enhancing nitric oxide (NO) manufacturing.^[1,2]

The up to date Glaxon Plasm Surge V3 Substances. Comparisons to V1 and V2 are on the backside of this text.

Previously, arginine was the complement trade’s go-to NO precursor, however current years have seen citrulline change it as a result of latter’s superior bioavailability.^[3] Citrulline is simpler at boosting NO as a result of, in contrast to arginine, it doesn’t fall prey to the primary cross impact, a phenomenon wherein ingested substances are damaged down within the abdomen earlier than reaching the intestinal wall.^[4-8]

That being mentioned, research present the mixture of citrulline and arginine is simpler than both ingredient alone^[1,9,10] – and, fortuitously, now we have each of them in Glaxon Plasm Surge V3!

Citrulline’s upregulation of NO comes with quite a few advantages, comparable to:

• Elevated oxygen uptake and top-end muscular energy^[11]
• Elevated athletic endurance. In a single 2010 examine, excessive doses of citrulline led to a 50% enhance in topics’ most bench press repetitions.^[12]
• Considerably decreased post-workout muscle soreness – as much as 40% discount in severity^[12]

Elevated blood circulate interprets to extra environment friendly nutrient and oxygen supply, in addition to sooner lactic acid clearance, which is essential for athletes since its accumulation results in post-exercise muscular fatigue and soreness.

As most of us know by now, when used alone, citrulline beats out arginine in relation to elevating nitric oxide ranges.^[2] However…. wait till you see what occurs when arginine is added!

Beta-Alanine – 3,200 mg

Beta-alanine has an extended historical past of use as an ergogenic assist. – it’s been a mainstay for the reason that starting of the dietary complement trade.

When beta-alanine is mixed with L-histidine, the result’s carnosine, a dipeptide molecule that’s ample in muscle tissue. Carnosine’s perform in muscle tissue is to assist take away lactic acid, a waste product that causes muscular fatigue when it accumulates.^[13]

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Thus, decreasing lactic acid accumulation, through beta-alanine supplementation, is a sensible method to bettering athletic endurance.

Regardless of carnosine’s advantages, it’s higher to take carnosine precursors somewhat than carnosine itself. The state of affairs is similar as that of citrulline versus arginine, with the precursor being extra orally bioavailable than the goal compound.

The bottleneck, in relation to carnosine manufacturing within the physique, is the quantity of beta-alanine out there to cells – beta-alanine is the rate-limiting issue.^[14,15] Therefore, supplementing with beta-alanine is an nearly surefire method to stimulating carnosine manufacturing, particularly since histidine, the opposite needed precursor, is ample in frequent meals.

Two giant meta-analyses analyzing over 40 peer-reviewed papers on beta-alanine discovered that the compound is handiest for enhancing endurance throughout train periods performed at a sustained depth, between 30 seconds and 10 minutes.^[13-20]

The three,200-milligram dose utilized in Glaxon Plasm Surge V3 is probably the most generally used and clinically validated by far.

A phrase in regards to the beta-alanine tingles

Upon taking beta-alanine, most people expertise a tingling sensation of their higher physique. Though it’d really feel unusual for first-time customers, the scientific consensus is that this tingling is innocent, and that beta-alanine is protected for human consumption.^[21]

L-Arginine – 2,000 mg

Arginine nitrate may appear to be an odd ingredient to indicate up in Glaxon Plasm Surge V3. In spite of everything, we mentioned earlier that oral arginine dietary supplements aren’t as efficient.^[4-8]

Nevertheless, there’s an exception to this rule. As we talked about in passing, when mixed, arginine and citrulline outperform both ingredient taken alone in each people^[9,10] and animals.^[1]

With the improved arginine standing, we get improved nitric oxide ranges, higher blood circulate and circulation… and finally, higher efficiency!^[10]

The synergistic results of arginine and citrulline are one cause arginine hasn’t fallen utterly out of style amongst savvy complement formulators.

The explanation this mix works is that the presence of citrulline inhibits arginase, the enzyme chargeable for breaking down arginine within the first cross impact we mentioned above. Because of this, extra arginine transits the intestine and is absorbed by the intestines,^[5,6] thus resulting in improved arginine bioavailability.

By combining arginine and citrulline, you’re getting much more NO than you’ll with citrulline alone, and thus higher impact sizes with all the advantages we mentioned within the citrulline part. However don’t fear, there’s much more arginine coming by means of Nitrosigine!

Astrolyte Electrolyte Mix (Fructooligosaccharides, Sodium Chloride, Magnesium Citrate, Potassium Citrate) – 1,770 mg

Glaxon’s in-house electrolyte mix, Astrolyte, is utilized in loads of their merchandise,together with Specimen, Specimen GFY, Plasm Surge, and Tranquility.

Glaxon Astrolyte deliver hydrating electrolytes in model. On this article, we dig deeper into the added mineral absorption ingredient, fructooloigosaccharides.

Astrolyte is made up of electrolyte minerals — sodium chloride, potassium, and magnesium — that play a vital position in muscle contractions and athletic efficiency, cardiovascular well being, bone density, insulin sensitivity, glycemic management, and blood stress.^[22-34]

These electrolytes are misplaced in sweat throughout intense exercises. So, for those who’re working arduous, it’s essential to replenish them for optimum efficiency and restoration.

We love electrolytes, however the inclusion of fructooligosaccharides (FOS) is what actually makes Astrolyte stand out. FOS is a particular carbohydrate that enhances mineral bioavailability (comparable to sodium, potassium, and magnesium), thereby multiplying the advantages related to electrolytes it’s stacked with.^[35-38] FOS additionally has a prebiotic impact by nourishing the helpful micro organism within the intestine.^[39]

Lastly, due to FOS, Astrolyte is naturally candy — roughly 0.3 to 0.6 instances as candy as sugar.^[40,41] This helps enhance the flavour of Glaxon Plasm Surge V3.

For additional info on this exceptional ingredient, click on by to our full-length article on Glaxon Astrolyte: Hydrating Electrolytes That Do Extra.

Nitrosigine (Inositol-Stabilized Arginine Silicate) – 1,500 mg

Nitrosigine is likely one of the most superior and efficient nitric oxide selling substances on the dietary complement market at present — it’s a patented type of arginine mixed with inositol and silica.^[42] You’ll see it on complement labels as inositol-stabilized arginine silicate, however in most analysis research, it’s known as ASI.

Nitrosigine vs. Different Nitric Oxide Substances^[43] Picture courtesy Nutrition21

In comparison with different substances like L-arginine, L-arginine AKG, L-citrulline, L-citrulline malate, and agmatine sulfate, in-vitro analysis confirmed that Nitrosigine can promote a higher increase in NO.^[44]

This type of arginine (ASI) stays intact for longer intervals of time, supporting higher blood ranges of arginine and nitric oxide.^[21] Nitrosigine is each fast-acting and long-lasting, taking impact as quickly as half-hour after ingestion, with results lasting as much as six hours.^[43,45]

Arginine, citrulline, and Nitrosigine?

Glaxon’s inclusion of Nitrosigine in Plasm Surge V3 is extraordinarily attention-grabbing. To grasp why, we have to talk about the historical past of arginine, citrulline, and the event of Nitrosigine.

As we talked about earlier, plain arginine fell out of favor with complement formulators as a consequence of its low oral bioavailability.^[5-8] That was the issue Nitrosigine was designed to resolve: Nutrition21 got down to construct a greater arginine, one that could possibly be absorbed extra effectively by the human digestive tract and wouldn’t want large doses.

Sure! We now have a full 1.5g dose of Nitrosigine for long-lasting pumps, endurance, and even some focus results!

As we additionally mentioned, the arginine precursor, citrulline, is commonly used to work round arginine’s bioavailability limitations.^[2] Nevertheless, you want giant doses of citrulline to attain maximal results,^[46,47] and people giant doses can result in GI misery.^[48,49]

Right here’s why the inclusion of Nitrosigine is attention-grabbing: It may well ship clinically important outcomes at a lot smaller doses, which is usually why Nitrosigine replaces arginine and citrulline in formulation.

What we nearly by no means see is arginine, citrulline, and Nitrosigine in the identical system!

Arginine within reason efficient by itself, citrulline even moreso; and like we mentioned, the mixture of arginine and citrulline has synergistic results.^[1,9,10] So, even simply with generic arginine and citrulline, Plasm Surge can be able to ship a great pump, particularly since they’re generously dosed.

Throw in a scientific dose of Nitrosigine on prime of all that, and all bets are off. In comparison with the everyday product entry, Glaxon Plasm Surge V3 seems to be to ship actually insane pumps.

Glaxon actually went massive on this one.

Nitrosigine analysis

A nitric oxide booster that improves cognition?! Sure – Nutrition21 handed round this useful infographic after the Nitrosigine cognition examine on wholesome younger adults was revealed.^[50]

In keeping with one examine, a 1,500 milligram dose of Nitrosigine can enhance flow-mediated dilation (FMD), a measure of arterial blood circulate, by 31%. As compared, an 8-gram dose of citrulline malate elevated FMD by 34%,^[51] that means that Nitrosigine produced roughly the identical impact measurement at roughly 1/5th the dose!

Glaxon, in fact, determined to take that examine and do each.

Nootropic results

NO boosters are usually mentioned within the context of maximizing bodily efficiency. Nevertheless, the cognitive results of optimized NO manufacturing are arguably simply as necessary! The mind is not any much less affected by circulation than another organ, in any case. The truth is, it has a disproportionately excessive demand for oxygen, ketones, and glucose circulating in your bloodstream.

And that is the place Nitrosigine provides much more clinically-studied advantages to Plasm Surge V3 — it’s particularly efficient at bettering cognitive efficiency.

• NO as a potent vasodilator also can enhance blood circulate within the mind, which can have cognitive advantages. One examine discovered that when Nitrosigine is taken previous to strenuous train, it could possibly forestall the short-term cognitive decline usually seen afterwards.^[52,53] Its cognitive advantages could even work inside quarter-hour of taking it!^[52]
• Nitrosigine supplementation has additionally been proven to enhance multitasking in wholesome younger males, even those that hadn’t exercised lately.^[54]
• One other examine confirmed that wholesome adults taking Nitrosigine carried out higher on a direct reminiscence check than these taking a placebo.^[50]

Sustaining peak cognitive efficiency is a vital a part of dealing with difficult exercise routines and avoiding burnout earlier than attaining one’s targets.

Nitrosigine use can doubtlessly result in a slight discount in blood stress. Picture courtesy Nutrition21

That’s why we see pre-workout formulation more and more counting on heavy nootropic assist, and we are able to’t consider a greater ingredient than Nitrosigine to play this position in Glaxon Plasm Surge V3.

When you’re taken with a extra in-depth dialogue of this superior ingredient, take a look at PricePlow’s earlier article on Nitrosigine titled “Nitrosigine: The Nitric Oxide Booster That Enhances Mind Operate“.

Amla (Phyllanthus emblica) [Fruit] Extract (Std. to 50% tannins as Capros) – 250 mg

Amla, a fruit tree with a wealthy historical past in Ayurvedic drugs, can also be acknowledged by two scientific names, Phyllanthus emblica and Emblica officinalis.

Its significance in East Asian tradition earned it the nickname “Indian gooseberry.” Amla has been used for hundreds of years to enhance cardiovascular well being and deal with circulatory problems.^[55]

How amla upregulates nitric oxide (NO)

Flashback: Todd Spear and Katie Emerson of Nutrition21 joined the PricePlow Podcast at SupplySide West 2022 for Episode #075 to speak analysis, tendencies, nitric oxide dietary supplements, and extra!

Fashionable analysis largely helps conventional information about amla. Sure antioxidants current in Indian gooseberries have been discovered to enhance endothelial perform whereas additionally stopping platelet formation,^[56] thereby decreasing the chance for severe cardiovascular occasions, comparable to coronary heart assaults and blood clots.

In research performed on animals, amla has demonstrated a noteworthy anti-hypertensive impact attributable to its stimulation of endothelial nitric oxide synthase (eNOS), which produces NO in arteries.^[57]

One cause amla can do that is due to gallic acid, a bioactive constituent that’s naturally ample in amla fruit^[58]. Analysis exhibits that gallic acid can forestall the oxidative degradation of eNOS, resulting in a bump in serum eNOS ranges and a corresponding enhance in NO manufacturing.^[59]

Gallic acid can also be a major bioactive constituent in tea, a beverage that’s famend for its cardiovascular advantages.^[60]

The connection between ATP and eNOS

Amla tree extracts are standardized for low molecular weight tannins (LMWTs). Some examples embody emblicanin-A, emblicanin-B, punigluconin, and pedunculagin.^[61]

When the physique metabolizes these tannins, they’re transformed into urolithins A, B, C, and D, all of which may considerably enhance mitochondrial perform.^[62]

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Your mitochondria are chargeable for producing mobile vitality within the type of adenosine triphosphate (ATP). Your physique makes use of ATP to do all the things, so, unsurprisingly, ATP manufacturing is positively correlated with improved well being and athletic efficiency.^[63,64]

That’s effectively and good, however what does ATP need to do with NO and pumps, that are imagined to be the main target of Glaxon Plasm Surge V3?

Because it seems, the most recent analysis exhibits that elevated ATP manufacturing can upregulate endothelial nitric oxide synthase (eNOS), enhance manufacturing of nitric oxide (NO), and enhance arterial perform.^[65] This occurs as a result of when crimson blood cells, platelets, and endothelial cells launch ATP in response to stimuli, calcium is upregulated inside endothelial membranes, inflicting the translocation of eNOS into endothelial cells, the place it’s activated to supply NO.^[65]

Right here is how one professional describes the method:

As soon as launched, ATP binds to purinergic (P2X and P2Y) receptors on endothelial cells. Binding leads to the endothelial cells releasing nitric oxide through endothelial nitric oxide synthase, prostacyclin, and endothelium-derived hyperpolarizing issue, all 3 of which have an effect on the sleek muscle of the vasculature through cyclic guanosine monophosphate, cyclic adenosine monophosphate, and hyperpolarization, respectively.^[66]

Amla’s different advantages

Other than its position in ATP upregulation, urolithin B may additionally have anabolic results.^[67]

Lastly, Amla extracts also can enhance cognitive efficiency.^[68]

L-Glutathione Diminished (as Setria) – 200 mg

The assorted iterations of Plasm Surge have lengthy included Setria, a trademarked type of the extremely bioavailable L-Glutathione. Glutathione (GSH), as most of us have most likely heard by now, is an endogenous antioxidant (i.e. produced by your individual physique) that scavenges free radicals and protects cells from oxidative injury.

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Setria’s modern fermentation course of has enabled the manufacturing of a GSH that has been clinically confirmed to boost serum GSH ranges, making it simpler than generic GSH dietary supplements. Moreover its superior bioavailability, Setria is a widely known standardized glutathione complement that’s been in Plasm Surge for some time.

Though your physique can produce GSH by itself, beneath sure circumstances it may be helpful to provide it with exogenous GSH for the aim of enhancing well being and efficiency.^[69]

For instance, Setria has been proven to assist immune system functioning by enhancing cleansing and combating oxidative stress,^[70] making it a doubtlessly helpful complement for pathogenic an infection.

Might synergize with citrulline

Though it’s mostly utilized in well being and wellness dietary supplements, Setria is showing increasingly more in performance-focused formulation like Glaxon Plasm Surge V3 due to key cardiovascular advantages, like bettering blood circulate and pumps when stacked with citrulline.^[71,72]

Analysis has proven that combining Setria and L-citrulline can doubtlessly result in synergistic and sustained will increase in nitric oxide manufacturing.^[71] Different analysis has discovered that this mix also can result in synergistic will increase in lean muscle mass and muscular power in comparison with each citrulline malate and a placebo. Extra analysis is required to substantiate these findings.^[72]

The Setria dose utilized in these research was 200 milligrams, the identical dose in Plasm Surge V3.^[71]

AstraGin (Astragalus membranaceus and Panax Notoginseng) [Root] Extract – 25mg

To be able to maximize bioavailability, Glaxon makes use of 25 milligrams of AstraGin in Plasma Surge.

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AstraGin is a patented proprietary mix of Astragalus membranaceus and Panax notoginseng root extracts from NuLiv Science.^[73-77] Whereas it affords quite a few advantages, its fundamental benefit is a capability to reinforce bioavailability and nutrient absorption.

Preliminary research counsel that AstraGin can activate a number of transporters within the small gut, thus bettering their uptake of vitamins, together with amino acids, creatine, and omega-3 fatty acids.

As a result of we’ve been speaking loads about arginine’s poor oral bioavailability, it’s price mentioning {that a} 2017 examine demonstrated AstraGin considerably improves L-arginine absorption.^[78] This clearly makes it a useful ingredient for the Glaxon Plasm Surge V3 system, which options one of many largest arginine doses we’ve seen shortly.

Furthermore, some analysis signifies that AstraGin can assist total intestine well being by combating intestine irritation and bettering the structural integrity of intestinal tissue.

Pyrroloquinoline Quinone (PQQ) – 5 mg

Attention-grabbing: 20mg every day PQQ supplementation offers all types of cognitive and psychological advantages. We don’t have this a lot of a dose right here, however assume we needs to be seeing PQQ extra typically!

Pyrroloquinoline quinone (PQQ) is a disodium salt that’s able to growing mitochondrial biogenesis,^[79,80] the method by which the physique generates new mitochondria. PQQ does this by upregulating sirtuin 1 (SIRT1), an enzymatic protein with unbelievable advantages for well being and longevity.^[79]

Higher mitochondrial density means extra ATP, which results in, as we’ve mentioned, NO upregulation, improved circulation, and higher oxygen utilization.^[81]

PQQ’s results on circulation can really enhance cognition,^[82] very like Nitrosigine. When taken over lengthy intervals of time, PQQ supplementation can result in reductions in perceived stress, elevated vitality ranges, and higher sleep high quality.^[83]

Once more, the addition of PQQ is an indication that Glaxon supposed to use the ATP-NO connection to the fullest with this Plasm Surge redesign.